Keywords

Optogenetics, 2-photon activation, large scale electrophysiological recordings, mouse model

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Project summary

The aim of this project is to study how information about sound frequency or intensity are propagated along the auditory pathway. To understand how sound features are encoded in the brain we would need to vary specific parameters of the input and measure how it affects neuronal firing. Recent progress in optogenetics have allowed to activate neuronal circuits precisely. Here we will use these tools to control the cochlear output and activate optogenetically cochlear hair cells in vivo. Optical methods allow to focalize the beam of a laser onto several cellular targets and rapidly update the temporal pattern of stimulation. The postdoc will develop a setup based on holographic light patterning to be able to stimulate simultaneously (but independently) single hair cells with millisecond precision. Concurrently, we will perform recordings from large populations of neurons at different stages of the auditory pathway using multi-electrode arrays.

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More information and contact: https://research.pasteur.fr/en/job/postdoc-position-in-auditory-neuroscience/